The “It’s Free Real Estate” meme is from a part of the Tim & Eric Awesome Show, Great Job! From that clip, there was a popular GIF that came where the guy in the frame turns to the camera smugly and says “It’s Free Real Estate”, referring to of course, free real estate.
The original video can be seen here.
The video came out in 2012 and within the Tim & Jim fanbase, “It’s Free Real Estate” was more of an inside joke. It wasn’t until April of 2018 where the guy turning to the camera saying “It’s Free Real Estate” became a meme which was used to make a joke of anyone/anything taking the space or location of something else unhindered.