It’s the penguin from Madagascar. The caption is “Kowalski, Analysis”. It’s used in the context of a slightly confusing situation where the outcome is either ironic or not known. There’s really not a whole lot to it. That’s it. This is just one of those memes that became a meme for no apparent reason.
The “Am I A Joke To You” meme features a serious looking man simply with the caption, “am I a joke to you?” It came from a screen shot from South African soap opera Generations the Legacy where the character in the frame (Mziwoxolo ‘Tau’ Mogale) is asking the memed question.
The NPC Meme is more of a right wing / conservative meme that portrays leftist and liberal minded individuals as “NPCs”, which stands for Non Playable Character. This term is often used in regards to video games where the NPCs are characters in the game which are not operated by an person, player or human. Instead, they are just programmed characters following a script which advances the story.